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Investigating the effect of oil spills
on the environment and public health.
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Alexis M. Temkin

Medical University of South Carolina

Marine Biomedicine and Environmental Sciences

HCC Room H0354
86 Jonathan Lucas St.,
Charleston , SC  29425  

temkin@musc.edu

Project List:

Using Embryonic Stem Cell Fate to Determine Potential Adverse Effects of Petroleum/Dispersant Exposure

Year 3-5 Investigator Grants (RFP-II)Role: Research Staff, Graduate Student - PhD Level, GoMRI Scholar

Publications & Presentations:

Journal Articles - 3

2016

Bowers, R. R., Temkin, A. M., Guillette, L. J., Baatz, J. E., & Spyropoulos, D. D. (2016). The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers. General and Comparative Endocrinology, 238, 61-68.
Temkin, A. M., Bowers, R. R., Magaletta, M. E., Holshouser, S., Maggi, A., Ciana, P., Guillette, L. J., Bowden, J. A., Kucklick, J. R., Baatz, J. E., & Spyropoulos, D. D. (2016). Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPAR <b>γ</b> Activity <i>in Vitro</i> and <i>in Vivo</i> : Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen. Environmental Health Perspectives, 124(1), 112-119.

2014

Temkin, A. M., & Spyropoulos, D. D. (2014). Induced pluripotent stem cell technology and aquatic animal species. Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology, 163, 3-13.

Conference Presentations - 27

2016

Cantu, T. B., J.A.; Temkin, A. S., & D.D.; Guillette, L. J. (2016). Eicosanomics: Novel Approaches to Investigate the Effect of Oil/Dispersant Exposure on Eicosanoid Biosynthesis in Sentinel Species. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2016
Cantu, T. B., J.A.; Temkin, A. S., & D.D.; Guillette, L. J. (2016). Life Lessons From Wildlife And Lou: The Tale Of Pansteatitis And Use Of Novel Eicosanomic Techniques To Assess Inflammation In Sentinel Species. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2016
Spyropoulos, D. T., A.M.; Cantu, T. M., N.A.; Williams, C. B., R.R.; Bowden, J. K., J.R.; Kohno, S. B., & J.E.; Guillette, L. (2016). From Oiled Stem Cells to Pregnant Women: Methodically Navigating Between Complex Environments and Human Health. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2016
Temkin, A. B., R.R.; Baatz, J. S., & D.D (2016). Rapid and sensitive assay screening reveals multiple potential hormone disrupting activities in MC252 crude oil and different dispersants. In 25 Years of Endocrine Disruption Research: Past Lessons and Future Directions
Temkin, A. B., R.R.; Baatz, J. S., & D.D (2016). Characterization of DOSS as on Obesogen In Vivo. In 7th Society of Environmental Toxicology and Chemistry (SETAC) World Congress/SETAC North America 37th Annual Meeting
Temkin, A. B., R.R.; Baatz, J. S., & D.D (2016). Characterizing DOSS as an Obesogen In Vivo. In Gordon Research Conference, Environmental Endocrine Disruptors
Temkin, A. B., R.R.; Guillette, L. B., J.A.; Kucklick, J. B., & J.E.; Spyropoulos, D. (2016). In vivo Exposure and Stem Cell Transcriptomics To Determine If Dioctyl Sodium Sulfosuccinate (DOSS) Is A Bona Fide Obesogen. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2016
Temkin, A. B., R.R.; Magaletta, M. H., S.; Maggi, A. C., P.; Guillette, L. B., J.A.; Kucklick, J. B., & J.E.; Spyropoulos, D. (2016). DOSS in Corexit and in Laxatives: Finding a Poster Child for Encouraging Movement in Dispersant and Obesity Sciences. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2016
Temkin, A. B., R.R.; Sojka, C. A., M.; Guillette, L. B., J.A.; Kucklick, J. B., & J.E.; Spyropoulos, D. (2016). Rapid and sensitive assay screening reveals multiple potential hormone disrupting activities in MC252 crude oil and different dispersants. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2016

2015

Sojka, C. T., A.M.; Bowers, R. S., & D.D (2015). Effects of Crude Oil and Dispersant Mixtures on PGR and AR Activity. In 2015 Medical University of South Carolina, HML Poster Session of the Summer Undergraduate Research Program: Endocrine Disrupting Compounds, the Environment and Human Health.
Sojka, C. T., A.M.; Bowers, R. S., & D.D (2015). Effects of Crude Oil and Dispersant Mixtures on PGR and AR Activity. In 2015 Medical University of South Carolina Summer Undergraduate Research Program Oral Presentations
Temkin, A. B., R.; Baatz, J. G., & L.; Spyropoulos, D. (2015). Evaluating the endocrine disrupting potential of crude oil and dispersant via transactivation assay screens. In SETAC North America 36th Annual Meeting
Temkin, A. B., R.; Baatz, J. G., & L.; Spyropoulos, D. (2015). Identification and characterization of putative obesogens in crude oil and dispersants used in the deepwater horizon oil spill. In SETAC North America 36th Annual Meeting
Temkin, A. B., R.; Baatz, J. G., L.J.; Kohno, S. S., & D.D (2015). Keynote Speaker: Empowering Awareness of Environmental Impacts on Women's Health - From Wildlife and Stem Cells to the Clinic and Personal Choices. In Carolina Women’s Health Research Forum
Temkin, A. B., R.R.; Guillette, L. S., & D.D (2015). RFP-II: Using Embryonic Stem Cell Fate to Determine Potential Adverse Effects of Petroleum/Dispersant Exposure. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2015
Temkin, A. B., R.R.; Magaletta, M. H., S.; Maggi, A. C., P.; Guillette, L. B., J.A.; Kucklick, J. B., & J.E.; Spyropoulos, D. (2015). Predicting Long Term Impacts of Oil/dispersant Exposures on Human Health and Higher Trophic Organisms: Obesogenicity. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2015

2014

Andersen, M. T., A.M.; Bowers, R. S., & D.D (2014). Assessing Crude Oil and Dispersant Activation of Nuclear Receptors. In MUSC Marine Biomedicine & Environmental Sciences Program, Summer Undergraduate Research Program Student Colloquium
Andersen, M. T., A.M.; Bowers, R. S., & D.D (2014). Assessing Crude Oil and Dispersant Activation of Nuclear Receptors. In Summer Undergraduate Research Program, Final Presentation Day
Barrett, N. T., A.; Ellisor, D. K., S.; Guillette, L., & ; Spyropoulos, D. (2014). Histological Analysis of Adipose Tissue in the Tail of American Aliigators Exposed to Tributyltin in ovo. In MUSC Marine Biomedicine & Environmental Sciences Program, Summer Undergraduate Research Program Student Colloquium
Barrett, N. T., A.; Kohno, S. G., L.J, ;. S., & D.D (2014). Histological Analysis of Adipose Tissue in the Tail of American Aliigators Exposed to Tributyltin in ovo. In Summer Undergraduate Research Program, Final Presentation Day
Magaletta, M. T., A.M.; Bowers, R. S., & D.D (2014). Sub-fraction Toxicities of Gulf Oil and Corexit Water Accommodated Fraction and Their Ability to Drive Stem Cell De-Differentiation at Sub-Lethal Exposure. In MUSC Marine Biomedicine & Environmental Sciences Program, Summer Undergraduate Research Program Student Colloquium
Magaletta, M. T., A.M.; Bowers, R. S., & D.D (2014). Sub-fraction Toxicities of Gulf Oil and Corexit Water Accommodated Fraction and Their Ability to Drive Stem Cell De-Differentiation at Sub-Lethal Exposure. In Summer Undergraduate Research Program, Final Presentation Day
Patton, M. T., A.; Ellisor, D. K., S.; Guillette, L., & ; Spyropoulos, D. (2014). Using Molecular Markers to Rapidly Characterize Adipogenic Stem Cell Differentiation. In 2014 Annual Meeting of SICB
Temkin, A. B., R.; Ellisor, D. B., J.E.; Kucklick, J. K., & S.; Guillette L. J.; Spyropoulos, D. (2014). Predicting Long Term Impacts of MC252 Oil/COREXIT Exposures on Human Health and Higher Trophic Organisms: Obesogenicity. In Gulf of Mexico Oil Spill & Ecosystem Science Conference 2014
Temkin, A. B., & R.; Spyropoulos, D. (2014). Predicting Long Term Impacts of Oil/dispersant Exposures on Human Health and Higher Trophic Organisms: Obesogenicity. In MUSC Marine Biomedicine & Environmental Sciences Program, Annual Student Research Open House

2013

Allen, E. T., A.M.; Newton D.A.; Mancia, A. B., & J.E.; Spyropoulos, D. (2013). Pygmy Sperm Whale (Kogia breviceps) progenitors undergo adipogenic differentiation under low oxygen tension unlike terrestrial mammalian progenitors. In 6th Aquatic Animal Models for Human Disease
Temkin, A. K., & J.; Spyropoulos, D. (2013). Predicting Long Term Impacts of Oil/dispersant Exposures on Human Health and Higher Trophic Organisms. In SETAC North America 34th Annual meeting